Baclofen
Generic Baclofen
Baclofen is used for treating spasm of skeletal muscles, muscle clonus, cramping of muscles, rigidity, spinal cord injury and pain caused by disorders such as multiple sclerosis.
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Talk to your doctor about other drug options that may work for you. Related: Alcohol Withdrawal. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, such as multiple sclerosis Baclofeh certain injuries to the spine. Traditional pharmacological Backofen for spasticity. Review A Bacloren assessment of baclofen in severe spinal spasticity. Baclofen produces its effects by activating the GABA B receptorsimilar to the drug phenibut which also activates this receptor and shares some of its effects. Baclofen may make your seizure control worse. Baclofen 20 mg-WAT, white, round. In the past decade, baclofen has been used with increasing frequency in the treatment of drug and alcohol addiction. Do not reduce the dose without talking to your doctor first. Drug holidays should only be in an inpatient setting with gradual withdrawal over 2 to 4 weeks. Baclofen may make your seizure control worse. For this drug to work well, a certain amount needs to be in your body at all times. With pump administration, a test dose is first injected into the spinal fluid to assess the effect, and if successful in relieving spasticity, a chronic intrathecal catheter is inserted from the spine through the abdomen and attached to the pump which is implanted under the abdomen's skin, usually by the ribcage. Blockers Glibenclamide Lonidamine Piretanide. Give today. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Talk to your doctor about how baclofen may affect your balance. Psychiatry Edgmont. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. L-type-selective : Bay K Taking it again could be fatal cause death. Baclofen acts on the central nervous system CNS to produce its muscle relaxant effects. Salvia divinorum. The absence of a warning for a given drug or drug combination in Baclofen way should be construed to indicate that the drug or combination is safe, effective or appropriate Bacllfen any given patient. The system battery typically lasts five years, at which time your doctor will need to replace the device. How and Backofen baclofen came to be used in the spinal sac intrathecally remains unclear, but as of [update]this has become an established method of treating spasticity in many conditions. Baclofensold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. Baclofen, at standard dosing, does not appear to possess addictive properties, and has not been associated with any degree of drug craving. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Taking it again could be fatal cause death. But if you remember just a few hours before your next scheduled dose, take only one dose. With oral use Manufacturer advises use with caution—no information available. Abrupt withdrawal of intrathecal baclofen may occur in patients using the drug over 2 months and may result in a hypermetabolic state with hyperpyrexia, impaired mental status, muscle rigidity, and severe rebound spasticity which may advance to rhabdomyolysis and multi-organ system failure. Check with your doctor or pharmacist before giving any other medicines to your child. For this medicine, the following should be considered:. Baclofen is used to treat pain and certain types of spasticity muscle stiffness and tightness from multiple sclerosis, spinal cord injuries, or other spinal cord diseases. For severe symptoms of an overdose, call What to do if you miss a dose: Take your dose as soon as you remember. All possible dosages and drug forms may not be included here. Baclofen is FDA-approved for the management of reversible spasticity, particularly for the relief of flexor spasms, clonus, and concomitant pain, common sequelae of spinal cord lesions and multiple sclerosis. Mechanism of Action Baclofen beta-[4-chlorophenyl]-GABA is an agonist at the beta subunit of gamma-aminobutyric acid on mono and polysynaptic neurons at the spinal cord level and brain. Baclofen is well tolerated by most people. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Baclofen may also be used to relieve other conditions as determined by your doctor. This could result in dangerous side effects. Do not drive or operate heavy machinery until you know how baclofen affects you. By using this site, you agree to the Terms of Use and Privacy Policy. Rare or very rare Withdrawal syndrome. Retrieved 3 March Pharmacokinetic characterization of baclofen in patients with chronic kidney disease: dose adjustment Badlofen. Drug Saf. Baclofen is a muscle relaxer and an antispasmodic agent. Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, cerebral palsyand multiple sclerosis. Muscle Nerve Suppl. To access free multiple choice questions on this topic, click here. Be careful if you drive or do anything that requires you to be alert. According to the Electronic Medicines Compendiumdosage Baclifen baclofen is increased and decreased gradually over time; initial high doses of baclofen, without tapering up to that amount, can cause side effects to be more severe. Baclofe workers, including nurse practitioners who prescribe baclofen, should educate the Bavlofen on the safe use of this drug. Review Intrathecal baclofen for severe spasticity secondary Baflofen spinal cord injury. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Baclofen should be avoided during pregnancy, especially during the first three months of gestation, as the drug crosses the placental barrier. Less common adverse effects are neuropsychiatric impairment, hypotension, peripheral edema, dyspnea, hypoventilation, pneumonia, seizure, insomnia, pain, speech alteration, depression, agitation, constipation, diarrhea, urinary frequency, incontinence, acute urinary retention, impotence, tremor, weakness, amblyopia, urticaria, and pruritus. Since the drug has shown promise in the treatment of alcohol and opioid addiction when assessed through clinical trials, off-label use of baclofen in addiction recovery continues to gain prominence. Muscle Nerve Suppl. Drugs and Supplements Baclofen Oral Route. If you have kidney disease, your doctor may start you at a lower dose.

Baclofen - for the

Baclofen is used to help relax certain muscles in your body. Besides those with spasticity, intrathecal administration is also used in patients with multiple sclerosis who have severe painful spasms which are not controllable Baclofem oral baclofen. If you drink alcohol, talk to your doctor before mixing with baclofen. Mar You can give your child medicines that contain paracetamol or ibuprofen, unless your doctor has told you not to. Your doctor Baclifen likely monitor certain health issues. There are other drugs available to treat your condition. This medicine may affect blood sugar levels. For people with kidney problems: If you have kidney problems or a history of kidney diseaseyou may not be able to clear this drug from your body well. Taking it again could be fatal cause death. Visit now. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. This information is not a substitute for medical advice. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. What to do if you miss a dose: Take your dose as soon as you remember. However, medicines can be used in different ways for different patients. This information is not a substitute for medical advice.

Baclofen - advise you

Symptoms can include trouble breathing and swelling of your Bacloofen or tongue. Alternative therapy for spasticity should be administrated simultaneously. Small, frequent doses are generally prescribed rather than larger doses. Are there Baclofen possible side-effects. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Baclofen is being studied for the treatment of alcoholism. Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. Therefore, large-scale prescription of baclofen for the treatment of AD seems premature and should be reconsidered. J Clin Pharmacol. Individuals with galactose intolerance, active peptic ulceration, and porphyria should not take this medication. In: StatPearls [Internet]. External link. Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Spasticity of cerebral origin is usually adequately managed on 90 to mcg daily. If you need to stop taking this drug, your doctor will slowly lower your dosage over time. Your doctor may do blood tests to check how well your kidneys are working. Baclofen should be avoided during pregnancy, especially during the first three months of gestation, as the drug crosses the placental barrier. It usually is taken 3 times a day at evenly spaced intervals. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful Baclofwn improving your condition. Present in milk—amount probably too small to be harmful. Currently, baclofen continues to be given by mouth, with variable effects. Abrupt withdrawal is more likely to result Bac,ofen severe withdrawal symptoms. Interactive image. Bxclofen baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, Baclofwn multiple Bqclofen. For this medicine, the following should be considered:. Also tell your health care professional if you have any other types Baclofe allergies, such as to foods, Baclofsn, preservatives, or animals. It is slightly soluble in water, very slightly soluble in methanoland insoluble in chloroform. The dose will be shown on the medicine label. Discontinuation of baclofen can be associated with a withdrawal syndrome which resembles benzodiazepine withdrawal and alcohol withdrawal. A case report published in Therapeutic Advances in Psychopharmacology in suggested that baclofen might be effective for treating marijuana dependence, particularly for those who have used the drug heavily for a long time. Besides those with spasticity, intrathecal administration is also used in patients with multiple sclerosis who have severe painful spasms which are not controllable by oral baclofen. Dario A, Tomei G. Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen. Baclofen produces its effects by activating the GABA B receptorsimilar to the drug phenibut which also activates this receptor and shares some of its effects. The use of drinks that contain alcohol can increase your risk of nervous system side effects such as drowsiness, dizziness, and difficulty concentrating on tasks from baclofen. Reports of overdose indicate that baclofen may cause symptoms including vomitinggeneral weaknesssedationrespiratory insufficiencyseizuresunusual pupil size, dizziness, [14] headaches, [14] itchinghypothermiabradycardiahypertensionhyporeflexiacomaand death. A prescription for this medication is refillable.
Common use

Baclofen is used for treating spasm of skeletal muscles, muscle clonus, cramping of muscles, rigidity, spinal cord injury and pain caused by disorders such as multiple sclerosis. Baclofen acts by relaxing skeletal muscles, the muscles that move the skeleton (and also called striated muscle).



Dosage and direction

Take Baclofen exactly as it was prescribed by your doctor. Do not take the medication in larger doses, or take it for long time. Take this medicine by mouth with a drink of water. Swallow it. The usual initial dose of Baclofen for adults is 5 mg given three times daily. The dose can be increased by 15 mg every three days to a maximum of 80 mg/day in divided doses.



Precautions

Your doctor needs to know you medical history, especially about kidney disease, diabetes, seizures, stroke, an unusual or allergic reaction to Baclofen, other medicines, foods, dyes, or preservatives. You should tell you doctor if you are pregnant or trying to get pregnant and if you are breast-feeding. If you suddenly stop taking your medicine, you may develop a severe reaction. The dose will be slowly lowered over time to avoid any side effects and your doctor have to control this process. Follow the advice of your doctor. You may get drowsy or dizzy when you first start taking the medicine or change doses. You should stand or sit up slowly. Do not drive, use machinery, or do anything that may need your attention and can be dangerous. Stop this kind of activity until you know how the medicine affects you.



Contraindications

Patients with an allergy to Baclofen should not take it. Before taking Baclofen, tell your doctor about your allergy to any other drugs. Also if you have kidney disease; epilepsy or other seizure disorder; or a history of stroke or blood clots, you have to discuss it with your doctor and it is possible that you will not take this drug.



Possible side effects

There are list of side effects that you should immediately inform your doctor or health care professional about. It includes allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, constipation, low blood pressure, hallucinations, vomiting, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention, seizure. Also there are other list of side effects that usually do not require medical attention but you should tell your doctor or health care professional if they continue or are bothersome. It includes confusion.



Drug interactions

Baclofen may interact with next medicines and products such as alcohol, antihistamines, medicines for depression, anxiety, and other mental conditions, medicines for pain like codeine, oxycodone, tramadol, and propoxyphene, medicines for sleep, phenobarbital. Use of Baclofen with other drugs may lead to additional reduction in brain function. For example, the use of Baclofen and tricyclic antidepressants together may cause muscle weakness; the use of Baclofen and monoamine oxidase inhibitors can result in greater depression of brain function as well as low blood pressure.



Missed dose

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.



Overdose

If you think you have taken too much of this medicine you should immediately contact a poison control center or emergency room.



Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed and out of children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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