Generic Clonidine (Clonidine )
Clonidine is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs.
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Rare or very rare Alopecia Clinidine atrioventricular block ; dry eye ; gynaecomastia ; intestinal pseudo-obstruction ; nasal dryness. Drug Status Rx. StatPearls [Internet]. This allows your blood vessels to relax and your heart Cloniidne beat more slowly and easily. Hypertension, and later hypotension, may arise. About About Drugs. If continued medication treatment is clinically indicated, consideration of another ADHD medication may be warranted. Your dose, form, and how often you take it will depend on:. If there is a clear and positive response to the medication and no or minimal adverse effects, dose adjustments may be more frequent, as long as more frequent communication occurs with the caregiver s and school personnel. You are viewing BNF. Serious side effects can include:. Clonidine hydrochloride is an imidazoline derivative that acting centrally on alpha-2 adrenergic as an agonist. Dose adjustments Use with caution in severe impairment—reduce initial dose and increase gradually. There are other medications available Clonifine treat your condition. Article Contents. Clnidine can also cause other side effects. For people with eye problems: This includes dry eye syndrome and problems focusing your eyes. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. The form you use may depend on your condition. Anaesth Crit Care Pain Med. Also, there is a test for phaeochromocytoma that is called the clonidine suppression test, in the lab, they measure the catecholamine levels before and after a dose of oral clonidine which, in healthy people, should cause the decrease in the level of catecholamines in circulation. The Catapres brand of clonidine is used to treat hypertension high blood pressure. Constipation ; depression ; dizziness ; dry mouth ; fatigue ; headache ; nausea ; postural hypotension ; salivary gland pain ; sedation ; sexual dysfunction ; sleep disorders ; vomiting. Data were further evaluated to compare groups consisting of only patients without a history of hypertension or groups with a history of hypertension. Advertising revenue supports our not-for-profit mission. Avoid using injection. Do not take a double dose to make up for a missed one. Information from Clonisine National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. By frequency [51] [54]. This binding has a sympatholytic effect, suppresses release of ClonixineATPrenin, and neuropeptide Y which if released would increase vascular resistance. Archived from the original on 8 November Clonidine may improve symptoms of attention deficit hyperactivity disorder in some people but causes many adverse effects Cloniidne the beneficial effect is modest. Review Why imidazoline receptor modulator in the treatment of hypertension? Australian Medicines Handbook ed. Clonidine was patented in and came into medical use in Related articles in Google Scholar. Amitriptyline Nortriptyline Imipramine. Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study. Clonidine therapy should generally be gradually tapered when discontinuing therapy to avoid rebound effects from occurring. Clonidinesold as the brand name Catapres among others, is a medication used to treat high blood pressureattention deficit hyperactivity disorderdrug withdrawal alcoholopioidsor smokingmenopausal flushingdiarrheaand certain pain conditions. Tolazoline may be an effective antidote to clonidine, although we do not have any experience with this drug. FP Essent. While urinalysis revealed that 26 of the pregnant women tested positive for the drug, only six women admitted to clonidine abuse. For example, clonidine will boost and increase how long an opioid high lasts. Sign In or Create an Account. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Frequency of monitoring can be reduced, usually to follow-ups Cloniine 1 to 3 months, depending on the patient's needs. Disclaimer: Our goal is to provide you with the most relevant and current information. The awkward case of 'his or her'. Per a report by the National Institutes of Healthin one study, 10 out of patients reported experiencing weakness from taking clonidine; four out of individuals experienced fatigue; and headaches and withdrawal symptoms occurred in one out of people. Titrate slowly and monitor vital signs frequently. In: StatPearls [Internet]. Many insurance companies require a prior authorization for the brand-name version of this drug. The Psychiatric Clinics of North America. Systemic Cponidine of alpha2- noradrenergic receptors. Avoid oral use unless potential benefit outweighs risk. Initial Dose 0. Your doctor can give you advice on the best tapering schedule. Therapeutic Advances in Gastroenterology. A potentially positive effect of taking clonidine is that it can help improve your sleep. In addition, clonidine releases norepinephrine into the prefrontal cortex area of your brain. This poster highlights the key GPCRs regulating vascular reactivity. Other overdose symptoms may include feeling cold, extreme weakness or drowsiness, weak or shallow breathing, pinpoint pupils, fainting, or seizure convulsions. A potentially positive effect of taking clonidine is that it can help improve your sleep. Keep this medication in the container it came in, tightly closed, and out of reach of children. The "adjustment for baseline" was an analysis of covariance ANCOVA where the covariate was the baseline version of the endpoint. Skip to main content. You may be at risk for more serious side effects if you already have low blood pressure or a low heart rate. Always speak Clonidin your healthcare Clpnidine about possible interactions with all prescription drugs, Clonidne, herbs and supplements, and over-the-counter drugs that you are taking. The extended-release tablet is usually taken once or twice a day with or without food. You may need to decide whether to stop breastfeeding or stop taking clonidine. Your dosage may be increased based on your blood Clonivine. It is also used in combination with other drugs to treat conditions like CClonidine deficit hyperactivity disorder ADHDaccording to Medline Plus. Search term. Individuals who have partaken in prolonged use of clonidine can become physically dependent on the substance. Other uses for this medicine What special precautions should I follow? Concentration 2 femtomolar picomolar nanomolar micromolar millimolar molar. It is not known whether this medicine will harm an unborn baby. Catapres is not approved for use by anyone younger than 18 years old. Have you used Clonidine hydrochloride? Your doctor will probably decrease your dose gradually over 2 to days for the regular tablet and 3 to 7 days for the extended-release tablet. Your review will help other researchers decide on the best products for their research. Frequency not known Accommodation disorder ; arrhythmias ; confusion. You may be able to tell this drug is working if you notice improvement in your symptoms, especially attention, hyperactivity, and impulsivity. Behavioral pharmacology. Clonidine Images. Other drugs may interact with clonidine, including prescription and over-the-counter medicines, vitamins, and herbal products. What other information should I know? Moxonidine Rilmenidine Tolonidine. Titrate slowly and monitor vital signs frequently. Little has been mentioned of cloni-dine's use for perioperative blood pressure reduction, although its use as an analgesic when given Clonidine the epidural or spinal route has been widely reported in the anesthesia literature. A significant result was again observed in the intraoperative blood pressure and pulse. The Journal of Substance Abuse Treatment published findings from a study regarding use and abuse of clonidine in those receiving treatment from a methadone maintenance program. Common side effect include dry mouth, dizziness, headaches, and sleepiness. Human and Experimental Toxicology. Central nervous system depression can also come about, as can respiratory depression. Keep all appointments with your doctor. Mental Health Clinician. Examples of clonidine in a Sentence Recent Examples on the Web The most common medications involved were cardiovascular drugs such as beta blockers, calcium antagonists and clonidine ; pain medications, including opioids and acetaminophen; and hormonal medications, including insulin. Older adults should not usually use clonidine because it is not as safe as other medications that can be used to treat the same condition. Ann Pharmacother. Clonidine extended-release long-acting tablets Kapvay are used alone or in combination with other medications as part of a treatment program to control symptoms of attention deficit hyperactivity disorder ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age in children. Retrieved 2 February

Common use

Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. It acts changing concentration of certain chemicals in blood and stimulating alpha2-adrenoceptors in the brain stem that reduces transmission of a signal from brain to other areas in the body. Its action results in a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.

Dosage and direction

Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. Do not use this drug if it was not prescribed to you by your physician. In case you use patches they should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When you change the patch for a new one, choose a different area of skin.


Avoid drinking alcohol, be especially attentive if you need to drive or make any work which requires high concentration of attention.


Hypersensitivity to Clonidine or any component of the formulation. Contraindication may also include in patients with sick sinus syndrome, bradicardia, atrioventricular block (degree II and III). Cautiousness should be exercised in cases of acute myocardial infraction, Reino syndrome, endogenous depression kidney failure and others.

Possible side effect

Beside of signs of allergic reaction such as hives, difficulty breathing, swelling such side effects may appear: fast or pounding heartbeats, a very slow heart rate, swelling, rapid weight gain, confusion, hallucinations, fever, pale skin, urinating less than usual. If you experience them seek for immediate medical attention.

Drug interaction

Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. Certain antidepressants may diminish pharmaceutical effect of Clonidine. Kidney damage maybe caused by increased concentration of Cyclosporine when Clonidine is administered concurrently. Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness.

Missed dose

If you missed a dose take it as soon as you remember, but if it is almost time of your next dose, just skip the forgotten dose. Do not try to compensate a missed dose by taking an extra one.


If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention.


Tablets and patches should be stored at room temperature 15-30 C (59-86 F) in a light- resistant container away from moisture.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.