If you have a low white blood cell count or have had one in the past, you must not take Clozaril. Take Clozaril exactly as prescribed by your doctor. Clozapine-induced agranulocytosis can be transient. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Your doctor will tell you Clozariil these tests are needed. If you are over 65 years old, you should Clozwril especially careful while taking this medicine. How to take Clozaril Follow all directions given to you by your doctor and pharmacist carefully. The effect of clozapine, however, is not at least in the short term reflected in measures of global functioning such as ability to leave the hospital and maintain an occupation. Incidence and risk factors in the United States". Of these, three have been fatal. Recent MI. Medical Information. The relapse rate is lower and patient acceptability is better. International Drug Price Indicator Guide. You can further our understanding of adverse events by reporting them to: Novartis Pharmaceuticals Canada Inc. If you develop abdominal pain it could be a sign of a breakdown of part of the intestine due to reduced blood supply which may lead to death. Taking Clozaril with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects.
||You may need urgent medical attention. You should monitor for Clozxril following symptoms: altered mental status, Clpzaril palpitations, high fever, irregular pulse or blood pressure, muscle rigidity muscle stiffnessand sweating. The reporting incidences for myocarditis from the Clozqril countries USA, United Kingdom, and Canada, data through Augustand Australia, data through March with Clozaril national registries can reliably be calculated. Reduce gradually over 1—2 weeks if discontinuing; can discontinue abruptly if necessary eg, severe neutropenia, others ; monitor for psychotic symptom recurrences or cholinergic rebound. For safety reasons, lab test results are recorded in patient registries. About About Drugs. This is not a complete list of side effects and others may occur. Many of these side effects can be managed, and some may go away on their own over time.
||Tell your doctor if you notice anything else that is making you feel unwell. Tell lCozaril doctor if you Clozwril or have ever had seizures. You may be more likely to get some of the side effects of Clozaril, such as rapid heartbeat, dizziness or lightheadedness due to low blood pressure, constipation and difficulty urinating. Daily news summary. Orthostatic hypotension, with or without syncope, can occur with clozapine treatment, especially when you first start taking it or your dose is changed.
Reasons for updating Change to section 6 - marketing authorisation holder Change to section 6 - marketing authorisation number. Healthwise, Healthwise for every health decision, and the Healthwise Cllzaril are C,ozaril of Healthwise, Incorporated. Journal of Chemical Cllzaril and Modeling. Retrieved 16 July Therapeutic Drug Monitoring. The risk of developing extrapyramidal symptoms, such as tardive Clozariil is below that of typical antipsychotics; this may be due to clozapine's anticholinergic effects. Clozapine can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. All data are for cloned human proteins. Neuroleptic malignant syndrome: A rare but serious effect called neuroleptic malignant syndrome has been reported with antipsychotic medications such as clozapine. These are direct effects that are also present in astrocyte cell cultures not containing neurons. You should tell your doctor if you use tobacco products before taking this medicine. Do not dispose of medications in wastewater e. According to the prescribing information, a increase in potassium levels was not a reported side effect of the medication. Clozafil Drug Monitoring. Concomitant strong CYP3A4 inducers: not recommended; if use necessary, may need to Clozaril
Clozaril dose and monitor. Clozapine is extensively metabolized in the liver, via the cytochrome P system, to polar metabolites suitable for elimination in the urine and feces. Springer Verlag. Clozapine pronounced as kloe' za peen. Clozapine may cause problems in newborns following delivery if it is taken during the last months of pregnancy. If your dose is more than 1 mL, use the larger 9 mL oral syringe. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Try to peel back the foil using dry hands.
Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines. It decrease the risk of suicidal behavior. It affects certain chemicals in the brain.
Dosage and directions
Take Clozaril as prescribed by your doctor. Take it with or without food. Take with food to reduce stomach irritation if stomach upset occurs. Continue to take the medicine even if you feel well. Do not stop taking it suddenly without your doctor's advice.
Tell your doctor about all your conditions, especially if you are pregnant or plan to become pregnant, breastfeeding, if you have any allergies, if you have a history of blood clots, blood problems, high blood cholesterol levels, heart problems, or lung or breathing problems, if you have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia, if you have poor health, diabetes, or a family member with diabetes, or you are very overweight, if you have decreased activity of enzymes that metabolize certain medicines.
You should not to take Clozaril if you have allergy to it, you have severe drowsiness, you have uncontrolled seizures (epilepsy) or loss of bowel muscle movement (paralytic ileus), you have bone marrow problems, other blood cell problems, or a history of blood problems caused by Clozaril, you are taking other medicines that may cause blood problems.
Possible side effects
The most common side effects are dry mouth, headache, dizziness, heartburn, increased sweating or saliva production, lightheadedness when you stand up; nausea; strange dreams; trouble sleeping; weight gain.
Severe side effects include: severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; calf pain or tenderness; chest pain; confusion; dark urine; decreased coordination; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased hunger, thirst, or urination; infection; involuntary movements of the tongue, face, mouth, or jaw (tongue sticking out, puffing of cheeks, mouth puckering, chewing movements); loss of appetite; numbness of an arm or leg; rapid breathing; restlessness; seizures; severe headache, dizziness, or vomiting; severe or persistent nausea or constipation; severe stomach pain; shortness of breath; stiff muscles; sudden, unusual weight gain; swelling of the hands, ankles, or feet; tremor; trouble swallowing; uncontrolled muscle movements; unusual mental or mood changes; unusual tiredness or weakness; vision changes; vomiting; yellowing of the skin or eyes.
Tell your doctor about all medicines you are taking and especially: benzodiazepines (lorazepam) or other medicines for mental or mood problems because the risk of heart or breathing problems may be increased; cimetidine, erythromycin, quinolone antibiotics (ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may increase the risk of Clozaril's side effects; barbiturates (phenobarbital), hydantoins (phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness ; antiarrhythmics (eg, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (chlorpromazine), or tricyclic antidepressants (amitriptyline) because the risk of their side effects may be increased by Clozaril.
If you miss a dose of Clozaril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking a dose of Clozaril for more than 2 days do not start taking it again. Contact your doctor right away for instructions.
Symptoms of overdose are drowsiness, slow or difficult breathing, dizziness, excessive salvation, fainting, coma, fast ot irregular heartbeats. If you suspect overdose seek medical attention immediately.
Store Clozaril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clozaril out of the reach of children and away from pets.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.