Search trials. This drug may cause irritation and bleeding in the bladder. What Cyclophosphamide Is Used For Cancers treated with cyclophosphamide include: Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic lymphocytic leukemia CLLchronic myelocytic leukemia CMLacute myeloid leukemia AMLacute lymphocytic leukemia ALLt-cell lymphoma mycosis fungoidesmultiple myeloma, neuroblastoma, retinoblastoma, breast cancer, ovarian cancer, and conditioning regimens for bone marrow transplantation Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. Notify your other physicians when taking this drug or have been given this in the past. High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion SIADH and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. Tablets should not be cut or crushed. However, research published in Clinical Cancer Research suggested that the molecular subtype luminal A breast cancer didn't benefit at all from adjuvant chemotherapy with Cytoxan. Archived from the original on 10 May Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes cytochrome P system in the liver to active metabolites. In some cases, health care professionals may use the trade name Cytoxan or Neosar when referring to the generic drug name cyclophosphamide. Cytoxan cyclophosphamide is a common chemotherapy drug that stunts or halts cancer cell growth. This is not a list of all drugs or health problems that interact with Cytoxan cyclophosphamide injection. Pathologic complete response with neoadjuvant doxorubicin and cyclophosphamide followed by paclitaxel with trastuzumab and pertuzumab in patients with HER2-positive early stage breast cancer: A single center experience. Cancerous cells lose this ability. The safety and Cytosan of dietary supplements and alternative Cytoaxn are often not known. The rash is Cytkxan by groups of small vesicles blisters sitting on a base of reddened skin, Cyytoxan may be extremely painful. Read all information given to you. Dosage Cyfoxan Administration. London, UK: Pharmaceutical Press. Self-Care Tips Drink at least two Ctyoxan three quarts of fluid every 24 hours, unless you are instructed otherwise. A study published in looked at the combination of Cytoxan and the drug docetaxel as neoadjuvant chemotherapy in HER2-negative primary breast cancer. Similarly, PCP may also be prevented in patients with vasculitis by having patients take certain types of antibiotics daily or every other day. Frequency not reported : Nasal congestionoropharyngeal pain, rhinorrhea, pulmonary venoocclusive disease, obliterative bronchiolitisalveolitis allergic, [ Ref ]. Genetic counseling is available for you to talk about the effects of this drug therapy on future pregnancies. Frequency not reported : Tinnituspremature labor, intrauterine death, fetal malformation, fetal growth retardation, fetal damage, carcinogenic effect on offspring [ Ref ]. You may get a drug called mesnawhich helps to decrease irritation and bleeding. Our Experts Our team includes expert hematologists and oncologists. How Cyclophosphamide Works Chemotherapy anti-neoplastic drugs : Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. Do not let anyone else take your medication.
Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.
Dosage and direction
For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.
Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.
Hypersensitivity, severe myelosuppression.
Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.
Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.
Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.
Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.
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