Dapsone
Generic Dapsone (Diaminodiphenyl sulfone)
Dapsone is used alone or co-administered with other drugs to treat leprosy and dermatitis herpetiformis (itching lesions on the elbows, knees, and scalp).
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Hepatocellular injury is characterized by elevated transaminases with liver biopsy showing predominantly eosinophilic lobular and portal infiltration. Management of nerve damage. Metronidazole Tinidazole Ornidazole. The patient had also received one dose of rifampicin which is unlikely to have caused such severe reaction. DeGowin RL: A review of therapeutic and hemolytic effects of dapsone. Monthly newsletter. Cancer Screening Overview. Contact us Submission enquiries: Access here and click Contact Us General enquiries: info biomedcentral. Using the escape key closes the listbox and puts you back at the textbox. Treatment of leprosy. Time Traveler for dapsone The first known use of dapsone was in See more words from the same year. Received : 02 February Drug Status Rx. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. Lepr Rev. Hepatitis may progress to liver failure and death [ 910 ]. Dapsone was stopped at admission. Lymphocytosis or eosinophils can join the infiltrating cells, and the affected portal tracts frequently demonstrate bile ductular proliferation with its attendant neutrophil response. Archived PDF from the original on 8 August He had fever, exfoliative dermatitis and lymphadenopathy cervical. Amikacin Kanamycin Streptomycin. The spread of drug-resistant malaria in Africa has encouraged the development of new, low-cost antimalarial drugs. Enhancement by clofazimine and inhibition by dapsone of production of prostaglandin E2 by human polymorphonuclear leukocytes in vitro. Effect of DDS on phytohemagglutinin-induced lymphocyte transformation. Topical dapsone gel will decrease the percentage of lesions in patients with mild to moderate acne, especially inflammatory lesions. It could be established that dapsone metabolites by their own have anti-inflammatory properties.

Dapsone - opinion

Gatifloxacin Moxifloxacin. Antibacterials : nucleic acid inhibitors J01EJ01M. For many Dapsone scientists attempted to develop a Dapsonw formulation of dapsone that would be as effective against acne as oral dapsone, but without the hemolysis side effect. Read the full article. Subscribe to Drugs. Edinburgh: Elsevier. J Med Assoc Thai. He was hemodynamically stable. Metronidazole Tinidazole Ornidazole. April Related Treatment Summaries Leprosy Pneumocystis pneumonia Other drugs classified as antimycobacterials, other. Examples of dapsone in a Sentence Recent Examples on the Web Oftentimes, dapsone is used alongside other acne treatments. Full size image. Prior Approvals. Artemisininanother antimalarial drug, had been developed in the s but was too expensive for large-scale use. Take dapsone exactly as directed. Dapsone Group: antileprosy agent Tablet: 25 mg, 50 mg, mg General information A sulfone that Dapsone of prime importance in the treatment of leprosy. However, dapsone can potentially cause severe side effects, meaning that sometimes steroids or other antibiotics should be used instead, although these alternative treatments are much less effective. World Health Organization. If you or someone else swallows dapsone, call your local poison control center at Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. Peptidoglycan layer Alanine analogue: Cycloserine. Orally administered dapsone is known to cause hematologic reactions, including met-hemoglobinemia; hemolysis, especially in patients with glucosephosphate dehydrogenase G6PD deficiency; and agranulocytosis. J Med Assoc Thai. Dapsone should be administered as part of combination therapy for prophylaxis of toxoplasmosis. By using this site, you agree to the Terms of Use and Privacy Policy. Especially publications about the Dalsone of dapsone in the therapy of Dpasone suggest that dapsone can be used Dwpsone in pregnancy. Retrieved Eosinophil peroxidase In comparison to Dalsone effect on neutrophils, those on eosinophils have been far less Dqpsone. Adult Treatment. Mayo Clin. Clin Pharmacokinet. Frequency not known Agranulocytosis ; appetite decreased ; haemolysis ; haemolytic anaemia ; headache ; hepatic disorders ; hypoalbuminaemia ; insomnia ; lepra reaction ; methaemoglobinaemia ; motor loss ; nausea ; peripheral neuropathy ; photosensitivity reaction ; psychosis ; severe cutaneous adverse reactions SCARs ; skin reactions ; tachycardia ; vomiting. Finally, dapsone has experienced a renaissance as reference molecule in organic chemistry as efforts are made to synthesize biologically active dapsone analogues like sulfoximine [ 31225]. Published : 11 August Whether the well-known therapeutic efficacy of dapsone in the therapy of brown recluse spider bites can be attributed to the aforementioned mechanism remains speculative [ ]. Steroid-sparing effects e. Unusual Cancers of Childhood Treatment. Grant Closeout. Dissociation of the inhibitory effect of dapsone on the generation of oxygen intermediates—in comparison with that of colchicine and various scavengers. August These mechanisms could be reproduced in mammalian cells [ 26 ]. Navigate this Article. Using a model of cultivated human keratinocytes, venom-induced activation of membrane phospholipids could be confirmed [ 45 ].
Common use

Dapsone is anti-infective medication used in combination with rifampicin and clofaziminein treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease) caused by Mycobacterium leprae, pneumonia caused by Pneumocystis jiroveci. In combination with pyrimethamine it is used to treat malaria



Dosage and direction

Take Dapsone with a full glass of water. To decrease upset stomach symptoms you may take this medication with food. Take this drug about each time the same day to get the most benefit from it. The dose of Dapsone depends on your condition. To treat leprosy in adults take 50-100 mg orally once daily for 2-5 years. Take 50 mg of Dapsone orally once daily to treat dermatitis herpetiformis. The recommended dose may be increased to 300 mg a day. To treat pneumocystis pneumonia in adults take 100 mg orally one time a day for two or three weeks. Follow all instructions of your doctor. Do not take more Dapsone than it was recommended.



Precautions

This medication may cause rare but fatal liver or blood problems which are characterized by such signs as bruising or pinpoint red spots on the skin, sore throat, fever, pale skin, jaundice and especially rash. Contact your doctor immediately if you experience the symptoms listed above. In rare cases may lead to serious, and even fatal, skin reactions. Inform your doctor if you have methemoglobin reductase deficiency (hemoglobin M), glucose 6-phosphate dehydrogenase (G6PD) deficiency, liver disease. Avoid exposing of your body to direct sun rays as this medication may cause increased skin sensitivity.



Contraindications

Do not use Dapsone in patients with hypersensitivity to the drug.



Possible side effect

If any sign of allergic reaction appear contact your doctor immediately. These include hives, rash, facial swelling, difficulty breathing. Inform your doctor immediately if you have pale skin, bruising or pinpoint red spots on the skin, sore throat, fever, jaundice, muscle weakness, numbness or tingling, bluish skin color, abdominal pain, difficulty breathing, unusual tiredness, dark colored urine or pale colored stools.



Drug interaction

Rifampin decreases blood levels of Dapsone. Folic acid antagonists such as pyrimethamine increase possibility of hematologic reactions.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

If you have such symptoms as excitation, seizures, nausea, vomiting, and bluish skin color contact your doctor immediately or seek emergency medical help.



Storage

Store tablets at room temperature between 15-30 C (59-86 F) in a dry tight container away from moisture and sunlight.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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