Listing a study does not mean it has been evaluated by the U. Tell your doctor if you are not able to eat or drink as you normally do. Mood stabilizers. Use effective birth control while using this medicine, and tell your doctor right away if you become pregnant. Your doctor may start you on a low dose of valproic acid and gradually increase your dose. In a patient who has epilepsy, quitting abruptly can cause seizures that will not stop status epilepticus. Related: Bipolar disorder. Talk to your doctor about the risks of using valproic acid during pregnancy. What should I do if I overdose on Depakote? Archived from the original on 6 Dpeakote Signs might include nausea or vomiting, loss of appetite, Dspakote pain, dark-colored urine, facial swelling, and yellowing of the skin or white of eyes. Depakote can cause suicidal thoughts or actions. Side Deoakote tend to be patient-specific so check with your doctor for further evaluation if this continues to be a concern. Source: Amundsen Group Analysis, November Limited, three case reports support its efficacy, however. All women of childbearing age including girls from the start of puberty should talk to their healthcare provider about using other possible treatments instead of DEPAKOTE. Outcome Measures. We comply with the HONcode standard for trustworthy health information - verify here. Antiepileptic medications have also shown to lower folate levels. Get our Free eNewsletter! In other projects Wikimedia Commons. If you suspect you've overdosed on this medication, Depakoote emergency medical attention or call a poison help line at Cases of pancreatitis among children and adults Ddpakote the medication have Depakote been DDepakote. Prevention of neurotransmitter-induced hyperexcitability of nerve cells, via Kv7. All women of child-bearing age should talk to their Depakore provider about using other possible Depkote instead of Depakote. What do I do if I miss a dose? You should not take Depakote if you have a history of liver disease, a urea cycle disorder, or a genetic disorder such Drpakote Alpers' disease a progressive degenerative disease of the central nervous system that occurs mostly in infants and childrenor Alpers-Huttenlocher syndrome the formal name for Alper's Disease. If the decision is made to use Depakote, you should use effective birth control. Persons with liver disease, mitochondrial disease, and urea cycle disorders are typically advised not to take Depakote. It is also recommended that people avoid alcohol and illegal drugs while on the medication, as they can worsen adverse effects. Withdrawal symptoms of Depakote can include irritability, anxiety, the return of manic or depressive symptoms, dizziness, and tremors. Archived from the original on 21 February Depakote Interactions. Expert Opin Drug Metab Toxicol. These are not all the possible side effects of Depakote. When added to antipsychotic drugs valproate probably increases the chance of improvement. Health insurance that you or a family member obtained through an employer or purchased privately. It is also used to treat seizures and prevent migraine headaches. Between 10 and 20 percent of people who take Depakote report being nauseous at some point. Do not crush, chew or split tablets. Can children take Depakote? Follow your doctor's instructions about taking this medicine while you are pregnant. Valproic acid may cause serious or life-threatening damage to the pancreas. Preliminary results of a phase-II trial". The Track It! Mood stabilizers. You may also contact the poison control center at Hide detailed description. They should be clear about the limits of the research around that medication and if Depakote are any other options. You can enroll in this registry by calling toll-free or by visiting the website, www. What should I know about storage and disposal of this medication? All children will receive active treatment at some point. Can symptoms occur if Depakote is discontinued? If you experience any of the following symptoms, call your doctor immediately: ongoing pain that begins in the stomach area but may spread to the back nausea, vomiting, or loss of appetite. The sodium salt of the acid is sodium valproate and a coordination complex of the two is known as valproate semisodium. This extreme drowsiness may cause you to eat or drink less than you normally would. Children under the age of two are at higher risk for liver damage when taking the medication. In order for valproate to work properly, it should be taken every day as ordered by your healthcare provider. These diagnoses are useful descriptively but they do not have specific treatment implications In the course of treating adolescents with explosive tempers and severe mood swings with Depakote divalproex sodiumthe investigators learned that younger children manifest symptoms that seemed identical to those constituting the adolescent disorder. February It also has histone-deacetylase-inhibiting effects.
Depakote contains Divalproex sodium, the substance which interacts with certain substances in the brain and increases the concentration of gamma-aminobutyric acid (GABA), which is a neurtransmitter. The drug is used to treat seizure disorders, the manic phase of bipolar disorders, to prevent migraine headaches.
Dosage and direction
The recommended initial dose for treatment of acute mania due to bipolar disorder is 750 mg daily taken in divided doses. For prevention of migraines take 250 mg twice daily. To treat seizures take initial dose calculated as 10-15 mg/kg/day, the dose should be increased gradually by 5-10 mg/kg/day every week to achieve the desired effect. Do not exceed the recommended dose and follow all recommendations of your health care advisor. Drink plenty of water during treatment. Liver function should be controlled on a regular basis to avoid harmful effects. Swallow the pill whole, do not crush or chew it. Inform your doctor immediately if you suppose that the medication does not work properly to prevent seizures. Do not stop taking the medicine without your doctor's permission even if you feel better.
Life-threating hepatic failure may develop, this is most likely to occur in children under two years of age especially if they if they have a metabolic disorder or a brain disease causing mental impairment (multiple sclerosis, Huntington disease, Creutzfeldt-Jacob disease, a brain injury or infection). Liver failure symptoms include malaise, lethargy, weakness, facial edema, vomiting, anorexia. Depakote also may cause rare cases of pancreatitis resulting in fatalities, which may suddenly appear even after several years of treatment with Depakote. Dose adjustment is needed in the patients with a bleeding or blood clotting disorder, a history of brain disorder, head injury, or coma, a family history of a urea cycle disorder, a family history of infant deaths with unknown cause, HIV or CMV (cytomegalovirus) infection. Suicide thoughts are also possible during treatment with the drug.
The medication cannot be administered to the patients with hepatic diseases, significant hepatic dysfunction known urea cycle disorders.
Possible side effect
The most common reported side effects are: nausea, somnolence, dizziness, vomiting, asthenia, abdominal pain, dyspepsia, rash, diarrhea, weight loss, tremors, low fever, dark urine, clay-colored stools. In some cases alopecia (loss of hair), itching and sensitivity to sunlight occur. More rare but serious adverse reactions include pancreatitis, liver injury, and abnormal bleeding. Liver is more likely to occur in children. The risk increases when a patient is taking two more more anti-seizure drugs. Symptoms of damaged liver are malaise, weakness, jaundice, swelling in the face, vomiting, loss of appetite.
The following drugs may interact with Depakote: topiramate (Topamax), tolbutamide (Orinase), a blood thinner such as warfarin (Coumadin), aspirin or acetaminophen (Tylenol), clozapine (Clozaril, FazaClo), diazepam (Valium), zidovudine (Retrovir), meropenem (Merrem), rifampin (Rifadin, Rimactane, Rifater), ethosuximide (Zarontin), indomethacin (Indocin), nabumetone (Relafen), ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), diclofenac (Voltaren, Cataflam, Arthrotec), ketorolac (Toradol) and aspirin. Such medicines as warfarin or heparin if used concomitantly with Depakote may affect blood clotting and lead to abnormal bleeding. Aspirin and felbamate (Felbatol) reduce catabolism of Depakote and hereby increase its blood concentrations. On the contrary phenytoin (Dilantin), Rifampin (Rifadin; Rimactane), carbamazepine (Tegretol) reduce its blood concentrations. Absorptin of Depakote is reduced by Cholestyramine (Questran), therefore intake of Depakote should be separated by at least two hours before or six hours after doses of cholestyramine.
Depakote can significantly increase concentrations in blood of lamotrigine (Lamictal), zidovudine (AZT), ethosuximide (Zarontin), diazepam (Valium) and phenobarbital, thereby increasing their concentrations in blood.
Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.
Depakote overdose symptoms include weak pulse, drowsiness, shallow breathing, somnolence, heart block, loss of consciousness, and deep coma. In case of the suspected overdose contact your doctor immediately and seek for immediate medical attention.
Store at room temperature 15-30 C (59-86 F) away from moisture and heat.
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