Contacts and Locations. Marketing Information. From Detrol La,
Detrrol free encyclopedia. When taken as directed, the active ingredient called Tolterodine Tartrate Extended Release will block cholinergic receptors located on the surface of the muscle cells. Take exactly as prescribed by your doctor. Tolterodine acts on M 2 and M 3  subtypes of muscarinic receptors whereas older antimuscarinic treatments for overactive bladder act more specifically on M 3 receptors. Solubility Ethanol. Epub Nov
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LA while you are pregnant, trying to become pregnant, or are breast feeding. Explore Apps. Abnormal bladder contractions that coincide with the urge to void can be measured by urodynamic studies. Keep a list of them with you to show your doctor or pharmacist each time you get a new medicine. Skip the missed dose if it is almost time for your next scheduled dose. Skip the missed dose if it is almost time LLa your next scheduled dose. Patients treated with DETROL LA experienced a statistically significant decrease in number of urinary incontinence per week from baseline to last assessment week 12 compared with placebo as well as a decrease in the average daily urinary frequency and an increase in the average urine volume per void. DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study. Detrol LA. These characteristics were balanced across treatment groups for all three studies. Fluoxetine, a potent inhibitor of CYP2D6 activity, significantly inhibited the metabolism of tolterodine immediate release in CYP2D6 extensive metabolizers, resulting in a 4. Weekly news roundup. Keep a list of all your medicines and show it to any healthcare provider who treats you. These include a total of patients randomized to DETROL LA 4 mg once daily and randomized to placebo enrolled in a randomized, placebo-controlled, double-blind, week clinical efficacy and safety study. Patients with the following conditions should be treated with caution: renal impairment, bladder outflow obstruction, gastrointestinal obstructive disorders, controlled narrow-angle glaucoma, and significantly reduced hepatic function. Therefore the drug should only used by pregnant mothers if the benefit to the mother outweighs the potential risk to the fetus. To make sure you can safely take Detrol LA, tell your doctor if you have any of these other conditions:. This may contribute to greater patient satisfaction with treatment, resulting in patients staying on treatment longer. Department of Health and Human Services. A total of pediatric patients Detro, DETROL LA, on placebo aged 5—10 with urinary frequency and urge incontinence were studied in two Ls, placebo-controlled, double-blind, week studies. Other Notes. Retrieved 22 December It is not known if it is present in the milk of nursing mothers. Diuretics : Coadministration of tolterodine immediate release up to 8 mg 4 mg bid for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic ECG effects. Tolterodine, although it acts on all types of receptors, has fewer side effects than oxybutynin M 3 and M 1 selective, but more so in the parotid than in the bladder as tolterodine targets the bladder more than other areas of the body. Drug Class. Behavioral techniques such as pelvic floor muscle exercises, or bladder training may provide additional benefit to the medication by helping the patient reassert control over his or her bladder. This includes prescription, over the counter, vitamin, and herbal products. QT c F msec manual. You can also visit www. Bucheon-si, Gyunggi-do, Korea, Republic of, Overactive Bladder OAB. If you try to ignore the signals, it may be Detrrol late and you have an embarrassing accident. Conditions Treated by Detrol LA Normally, your bladder muscle will expand to accommodate the urine until you receive the signal that it is time to empty your bladder. Alan D. Get emergency medical help if you have any of these signs of an allergic reaction: hives ; difficulty breathing; swelling of your face, lips, tongue, or throat.
Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.
Dosage and direction
Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose. If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function. Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.
Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome." This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery.
Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.
Possible side effect
Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.
Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).
Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.
Symptoms of overdose include blurred vision, dry mouth, and fast heartbeat.
Store at room temperature 15-30 C (59-86 F) away from moisture and heat.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.