After cleavage the immature virus proteins are assembled into particles which bud from the cell as mature, infectious virons. Indinavir may raise serum lipid parameters and blood glucose. Journal of Acquired Immune Deficiency Syndromes ;32 2 Search the site. National Library of Medicine U.
Indinavir - sorry, does Many people were skeptical of being too hopeful with indinavir due to previous events that occurred with AZT. What should I do if I forget a dose. Efficacy of indinavir-ritonavir-based regimens in HIVinfected patients with prior protease inhibitor failures. The study showed that the drug in combination with zidovudine and lamivudine significantly slowed the progression of AIDS. Other possible side effects of indinavir include: Diabetes and high blood sugar hyperglycemia. To make these copies, the cell uses proteins called enzymes. Wall Street Journal. Ask your pharmacist for a list of the ingredients. Inclusion in the list will enable Ranbaxy to provide indinavir at affordable prices to over 70 markets across the world. What is indinavir. A major reason for this fast approval was the presentation Merck gave to the committee with results from Study see below. Medicine portal. Indinavir can also cause kidney stones, but drinking a minimum of 1. Over time, as new copies of HIV are made in the body, the virus changes its structure. From Wikipedia, the free encyclopedia. Journal of Acquired Immune Deficiency Syndromes. Delavirdine, itraconazole, or Indinavir mg every 8 hours. It significantly increased life expectancies and decreased noticeable symptoms from infectious diseases that were the result of a weakened immune system from the virus. Call your doctor if you have any unusual problems while taking this medication. Loss of fat from the legs, arms, and face can also happen. Do not let anyone else take your medication. Your doctor will order certain lab tests to check your response to indinavir. Different mutations are associated with cross-resistance to different drugs. Because of the complex regimens and side effects associated with the use of indinavir, this drug is rarely used in Canada and other high-income countries. Information from the National Library of Medicine Inrinavir to participate in a study is an important personal decision. HIV can be passed to your baby if you are not properly treated during pregnancy. Indinavir, sold under the brand name Crixivan, is a type Incinavir anti-HIV drug antiretroviral called a protease inhibitor PI. Pain in the lower back and sides flankswith or without IIndinavir in the urine, is a symptom of kidney stones. Baseline human immunodeficiency virus type 1 phenotype, genotype, and RNA response after switching from Indniavir hard-capsule saquinavir to indinavir or soft-gel-capsule Indibavir in AIDS Indknavir trials group protocol About About Drugs. See also: Indinavir drug interactions in more detail. If your doctor has prescribed this "boosted" indinavir regimen, you still have to drink a minimum of 1. Summary Indinavir is a type of anti-HIV drug called a protease inhibitor. A combination of both drugs that is sometimes used is mg of indinavir with mg of ritonavir, both drugs taken every 12 hours. HIV Med. The purpose of this study is to evaluate the safety of giving indinavir and rifabutin at the same time simultaneously vs 4 hours apart staggered to HIV-positive and HIV-negative adults. Unlike the case when indinavir is the only protease inhibitor, indinavir in combination with ritonavir can be taken with or without meals. Indinavir has been associated with metabolic abnormalities including hyperglycemia, dyslipIdemia, and abnormalities in fat distribution. Key Clinical Trials Early studies of indinavir primarily focused on the combination of indinavir with two NRTIs usually zidovudine plus lamivudine as treatment for individuals with a history of zidovudine monotherapy. Do not breastfeed if you are infected with HIV or are taking indinavir. Take all of your HIV medicines as directed to control your infection. Then take your next dose at the regularly scheduled time.
Indinavir - charming message Continue to practise safer sex and take other precautions so as not to pass HIV on to other people. What special dietary instructions Indinavirr I follow. This list is not complete and Incinavir other drugs can interact with indinavir. Many drugs can interact with indinavir. Many people were skeptical of being too hopeful with indinavir due to previous events that occurred with AZT. When HIV infects a cell, it takes control of that cell. Although the risk of developing diabetes is generally low, symptoms that may be related to diabetes increased thirst, increased urination, unexplained weight loss, fatigue and dry, itchy skin should be discussed with your doctor. Back to Drug Profiles. These lists are not exhaustive. Views Read Edit View history. Because of its limited supply, Merck Indinavie to adopt a single distributor system in which they would send indinavir to only Indinavir pharmaceutical retail company. Wall Street Journal. Therefore other medications that are primarily metabolized by CYP3A4 may interact with indinavir. In both sets of studies milk thistle and vitamin C subjects were taking indinavir as the sole PI in their regimen. Journal of Acquired Immune Deficiency Syndromes. To reduce the risk of developing drug resistance, all anti-HIV drugs should be taken every day exactly as prescribed and directed. TRIM5alpha gene. IUPAC name. For example, M46I is Insinavir with cross-resistance to atazanavir, fosamprenavir, and nelfinavir but not to saquinavir ; V82A,F,T,S alone is associated with cross-resistance to ritonavir, but in combination with other mutations also confers resistance to atazanavir, fosamprenavir, nelfinavir, and saquinavir; I84V contributes to resistance against to all available protease inhibitors. Browse Drugs and Medicines. If the interaction on rifabutin is minimized, then the rifabutin levels may be suboptimal for treatment of tuberculosis in patients who are not administered the 2 drugs simultaneously. Adverse Effects Indinavir crystalizes in the urinary tract and causes kidney stones; thus individuals taking indinavir are advised to drink at least 1.
Indinavir is used to treat HIV infection in some patients when used in combination with certain other medicines. It is an HIV protease inhibitor. It works by slowing the growth of HIV, the virus that causes AIDS.
Dosage and directions
Take Indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take Indinavir with water. You may also take it with other liquids such as skim milk, juice, coffee, or tea. It is recommended to drink extra fluids.
Before using Indinavir discuss with your doctor if you are pregnant, planning become pregnant or breast-feeding, if you have allergy to food, medicines, or other substances, if you are taking any prescribed or not prescribed medications, herbal products, or dietary supplements, have cirrhosis, liver or kidney problems, diabetes, high blood sugar, high cholesterol, kidney stones, urinary problems (white blood cells in the urine), or blood problems (hemophilia hemolytic anemia).
Do not use Indinavir if you are allergic to its components; you are taking alfuzosin, amiodarone, astemizole, atazanavir, certain benzodiazepines (eg, alprazolam, oral midazolam, triazolam), cisapride, conivaptan, an ergot alkaloid (eg, ergonovine, ergotamine), erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, rosuvastatin, simvastatin), pimozide, a proton pump inhibitor (omeprazole), ranolazine, rifampin, salmeterol, a serotonin 5-HT1 receptor antagonist (eg, eletriptan, sumatriptan), St. John's wort, or terfenadine, sildenafil for pulmonary arterial hypertension (PAH).
Possible side effect
The common side effects are bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; nausea; tiredness; vomiting; weakness. Seek urgent medical attention if you experience the following severe side effects: allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back, flank, or side pain; bloody or cloudy urine; change in the amount of urine; changes in appetite; chest pain; chills; confusion; dark urine; fast or irregular heartbeat; fever; flushed face; heartburn; ingrown toenails; joint or muscle aches; mental or mood changes; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, or blistered skin; severe dizziness or fainting; severe or persistent stomach pain or upset; speech problems; swelling of the feet, hands, lower legs, or stomach; unusual hair loss; unusual paleness; unusual tiredness; unusually dry skin; vision changes; weight changes; yellowing of the skin or eyes.
Tell your doctor if you are taking any drugs especially about the following: amiodarone, astemizole, certain benzodiazepines (alprazolam, midazolam,triazolam), cisapride, ergot alkaloids (ergotamine), erythromycin, pimozide, salmeterol, or terfenadine; alfuzosin, conivaptan, certain HMG-CoA reductase inhibitors (atorvastatin, lovastatin, rosuvastatin, simvastatin), ranolazine, serotonin 5-HT1 receptor antagonists (eletriptan, sumatriptan), or sildenafil (for PAH); atazanavir; proton pump inhibitors (eg, omeprazole), rifampin, or St. John's wort.
If you miss a dose of Indinavir by more than 2 hours, do not take that dose. Take your next dose as scheduled. If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of Indinavir. Do not take 2 doses at once.
If you thin that overdosed Indinavir seek urgent medical help. Overdose symptoms are blood in the urine; diarrhea; lower back pain; nausea; vomiting.
Store Indinavir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in the original bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Indinavir out of the reach of children and away from pets.
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