Leukeran - consider
Extramural Research. Before taking chlorambucil, tell your doctor and pharmacist if you are allergic LLeukeran chlorambucil, Leumeran alkylating agents such as bendamustine Treandabusulfan Myleran, Busulfexcarmustine BiCNU, Gliadel Wafercyclophosphamide Cytoxanifosfamide Ifexlomustine CeeNUmelphalan Alkeranprocarbazine Mutalaneor temozolomide Temodarany other medications, or any of the ingredients in chlorambucil. Keep all appointments with the Leukerab. Take the missed dose as soon as you remember it. New York: Lrukeran. Advance Leueran. The cell cannot divide into 2 new cells if the 2 DNA strands cannot separate properly. If you forget a dose, take the missed dose as soon as you remember it. Using the escape key closes the listbox and puts you back at the textbox. Find a trial. Medicines can interact with certain foods. They also check how well your liver and kidneys are working. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Avoid close contact with people who have a cold, the flu, or other infections. To help decrease the risk of bleeding, use a soft toothbrush. Discontinue if skin reactions occur. Women of childbearing potential should use effective methods of birth control during your cancer treatment. Global Cancer Research. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements vitamins, minerals, herbs and others that you are taking at this time. Never try to catch up by taking two doses at once. The length of treatment depends on the Leujeran of drugs you are taking, how well your body responds to them, and the type of cancer you have. International Drug Price Indicator Guide. Mouthy ulceration. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Other drugs may interact with chlorambucil, including prescription and over-the-counter medicines, vitaminsand herbal products. Side Effects of Leukeran Back to Top. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. Bleeding or bruising. If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. Leukeran drug interactions in more detail. Before Leukean Leukeran, tell your doctor about all of your medical conditions including if you have:. Shown above, chlorambucil reacts with glutathione Lrukeran catalyzed by hGSTA leading to the formation of the monoglutathionyl derivative of chlorambucil. Chlorambucil's current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients. Uses of Leukeran Back to Top. National Cancer Institute. What should I know about storage and disposal of this medication? This medicine is available from a pharmacist and requires a prescription. Indications for LEUKERAN: Palliative treatment of chronic lymphatic lymphocytic leukemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease. Leukeran treats certain types of blood cancers. You usually have chemotherapy as a course of several cycles of treatment. They will monitor you closely during treatment and check how you are at your appointments. Retrieved 8 December US : D Evidence of risk. Schedule S4 Common side effects Bone marrow suppression. Indications for LEUKERAN: Leukwran treatment of chronic lymphatic lymphocytic leukemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease. Different drugs may affect different parts of the body. Lymphomas are cancers that originate in the Leukerqn system. This drug may be used as part of a combination therapy. Call freephone or email us. We comply with the HONcode standard for trustworthy health information - verify here. Ribonucleotide reductase inhibitor Hydroxycarbamide. Bone marrow suppression, seizures, fever, rash, hypersensitivity, urticaria, azoospermia, amenorrhea, sterility, hepato- and pulmonary toxicity, secondary malignancies, GI upset. This can cause your body to process drugs more slowly. Chlorambucil acts by preventing replication of tumour cells by forming cross-linkages between DNA strands. It works by sticking to one of the cancer cell's 2 DNA strands and stops them from separating. They also check how well your liver and kidneys are working.
For explanation: Leukeran
Chlorambucil is a chemotherapy drug and is Lekeran known by its brand name Leukeran. Other side Leukeran
not listed above may Leukerzn occur in some Leukerann. Product description What it looks like Leukeran tablets are brown, film-coated, round, biconvex tablets, engraved "GX EG3"on one side and "L" on the other. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. They check your levels of blood cells and other substances in the blood. We haven't listed all the side effects. Questions to Ask about Your Treatment. Consumer medicine information CMI leaflet Please read this leaflet carefully before you start using Leukeran. Chlorambucil's current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients. Use effective birth control to prevent pregnancy during treatment. Talk to your doctor for further details. Leukeran is the brand name Leu,eran generic Leukerna. Your doctor will also do tests to check if this drug is working. Talk to your doctor about this risk. However, because drugs affect each person Leukerann, we cannot guarantee Lejkeran this list includes all possible dosages. These drugs are cell cycle non-specific. Breastfeeding warning: It is not known if this drug passes into breast milk. Tell your Lrukeran right away if you experience any of the following symptoms of serious side effects:. Shipping for Prescription Medications Prescription medications are prepared by our pharmacy and shipped separately to ensure proper handling. Chemotherapy is most effective at killing cells that are rapidly dividing. Always inform your health care provider if you experience any unusual symptoms. Contact your doctor or nurse immediately if you have signs of infection, including a temperature above Taking other medicines Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your supermarket, pharmacy or health food shop. There are other drugs available to treat your condition. Use extra care to prevent bleeding while shaving or brushing your teeth. If your doctor tells you to stop taking Leukeran or you find that the expiry date has passed, ask your pharmacist what to do with any tablets left over. Do not take Leukeran if you are pregnant or breast feeding unless you and your doctor have discussed the risks and benefits involved.
Leukeran is a medication used to treat several kinds of cancer and other conditions including Hodgkin's disease (a type of lymphoma), malignant lymphoma (including lymphosarcoma), clasmocytoma, chronic lymphocytic leukemia, giant follicular lymphoma, hairy cell leukemia (a sub-type of chronic lymphoid leukemia), myeloma, ovarian cancer, breast cancer, Waldenstr?m macroglobulinemia (lymphoplasmacytic lymphoma), Letterer-Siwe disease (genetically stipulated proliferation of histiocytes), chorionepithelioma of the uterus, glomerular nephritis, Beh?et disease (a form of vasculitis), dermatomyositis, rheumatoid arthritis, sarcoidosis, uveitis, nephrotic syndrome. Leukeran's active substance is chlorambucil, a bifunctional alkylating agent.
Dosage and direction
Take exactly as prescribed by your doctor. Follow all instructions. The recommended initial dosage for short course of treatment is 0.1 to 0.2 mg/kg body weight (4-10 mg for an average patient) taken daily during 3-6 weeks. The daily dose may be taken as a single dose. In case of the sudden fall in th white blood count or bad tolerance by the patient the dosage should be carefully adjusted. Supporting course of treatment is administered individually.
Carefulness should be exercised in the patients with inhibited bone marrow function (expressed as leukopenia, thrombocytopenia, and anemia, including ones associated with a malignant process and on the background of the previous radiotherapy or chemotherapy), severe liver disease and kidney failure, acute gastrointestinal disease, in pregnant and breastfeeding women. Blood cell count,leukocytes count, platelets count, and Hb examination should be performed at least once weekly.
Leukeran cannot be used in the patients with hypersensitivity to its components (including other alkylating agents).
Possible side effect
The most common side effects are nausea, vomiting, changes in menstrual period. Contact your doctor immediately if you have following adverse reactions: painful or difficult urination, fever, chills, black, tarry or bloody stools, easy bruising or bleeding, blood in urine, swollen extremities, sores in mouth or on lips, small red spots on the skin, jaundice, cough, lower back or side pain, joint pain, abdominal pain, confusion, hallucinations, muscle twitching, agitation, trouble walking, weakness, paralysis.
Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you use.
If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. Skip the missed dose if it is almost time of your next dose. Do not try to compensate a missed dose by taking an extra one.
If you suspect overdose inform your doctor immediately about it and seek immediate medical attention. Signs of overdose are agitation, seizures, loss of balance or coordination.
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.