Generic Methotrexate
Methotrexate is an antimetabolite used to treat certain types of cancer.
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Methotrexate - agree

If you are female, you will need Methoteexate take a pregnancy test before you begin taking Merhotrexate. Call your doctor right away if you have trouble breathing, shortness of breath, chest pain, or a dry cough while taking this drug. This drug can make these problems worse. Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. An update". Get emergency medical help if you have signs of an allergic reaction Methorrexate methotrexate hivesdifficult breathing, swelling in Methotrexafe face or throat or a severe skin reaction fever, sore throatburning in your eyes, skin pain, red or purple skin rash that spreads and Methotdexate blistering and peeling. Show all parts of this monograph Drug action Indications and dose Unlicensed use Important Methktrexate information Contra-indications Cautions Interactions Side-effects Conception and contraception Pregnancy Breast feeding Hepatic impairment Renal impairment Pre-treatment screening Monitoring requirements Prescribing and dispensing information Patient and carer advice Medicinal forms Drug action Methotrexate inhibits the enzyme dihydrofolate reductase, essential for the synthesis of purines and pyrimidines. Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe. If you have psoriasis, your sores may get worse if you expose your skin to sunlight while you are taking methotrexate. What other information should I know? Risks and side effects to be aware of:. Methotrexate should not be used to treat psoriasis or rheumatoid arthritis if you have:. Every gift to the Arthritis Foundation will help people with arthritis across the U. You must use the correct dose for your condition.

Apologise: Methotrexate

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Methotrexate Accepted Author Manuscript. These drugs are often used to treat similar conditions. You should tell your doctor or nurse specialist straight Methotrexaate if you notice any of Methotreaxte following while taking methotrexate:. Important warnings. Methotrwxate Our Signature partners make their mark Metnotrexate helping us identify new and meaningful resources for people with arthritis. Call your doctor right away if you have any symptoms of this syndrome. Tell your doctor if you have or have ever had lung disease. Taking methotrexate more often, or changing the dose schedule may result in serious side effects. Discontinue breast-feeding—present in milk. You may need to have other tests, as you may not be able to take methotrexate. These infections can sometimes be very serious in people who are taking methotrexate. Withdraw treatment if ulcerative stomatitis develops—may be first sign of gastro-intestinal toxicity. You should speak to your doctor about this first. You are viewing BNF. If you are taking methotrexate to treat psoriasis or rheumatoid arthritis, your doctor may tell you to take the medication once a week.
Methotrexate To relieve painful mouth sores, a salt-water rinse or special mouthwash containing Methotrezate a pain reliever Methotrexate help. Medscape Reference. Skip to Content. If yes, what type of arthritis. Methotrexate can be toxic to your organs, and may lower your blood cell counts. Interactive image. Central nervous system reactions to methotrexate have been reported, especially when given via the intrathecal route directly into the cerebrospinal fluidwhich include myelopathies and leucoencephalopathies. The development of folic acid analogues had been prompted by the discovery that the administration of folic acid worsened leukemia, and that a diet deficient in folic acid could, conversely, produce improvement; the mechanism of action behind these effects was still unknown at the time. It is not to be confused with Aminopterin.
Keep your mouth clean by brushing Methotrxate teeth regularly. FDA alerts for all medications. Unneeded medications should be disposed of in special ways to ensure that Mwthotrexate, children, and other people cannot consume them. Effects on other treatments Methotrexate can sometimes be given along with other drugs to treat your condition. Most people are prescribed tablets. Learn how long they take, uses and side-effects. From Wikipedia, the free encyclopedia. How it makes you feel The correct dose of methotrexate commonly between 7. Supporting Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. Pharmacological Reviews. Folic acid supplements and monitoring tests are key for reducing your risk of methotrexate side effects. If you have gastroenteritis stomach upsetdo not take methotrexate until Metbotrexate have recovered. If you take too much: You could have dangerous levels of the drug in your body. What side effects can this medication cause? Methotrexate can harm an unborn baby or cause birth defects, whether the mother or father is taking this medicine. What about side effects? Tell your doctor if you have diarrheamouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling. Agonists: 8-Aminoadenine Adenine.

Methotrexate - matchless answer

Methotrexate was made in and initially came into medical Methhotrexate to treat cancer, as Methotrexate was less toxic than the then-current treatments. Dispose of the injected form of methotrexate in appropriate sharps Methotrsxate. By mouth, or by intravenous injection, or by intravenous Methotreexate, or by intra-arterial infusion, or by intramuscular injection, or by intrathecal injection For Adult consult product Methotrexxte. Merriam-Webster Dictionary. Methotrxate should also carry on taking methotrexate if your symptoms improve or if you start to feel better. Take the missed dose as soon as you remember it. Another possible side effect is nausea and vomiting. If you experience any of the following symptoms, stop taking methotrexate and call your doctor right away: mouth sores, diarrhea, black, tarry, or bloody stools, or vomit that is bloody or looks like coffee grounds. These symptoms include red, swollen, blistered, or peeling skin, rash, fever, red or irritated eyes, or sores in your mouth, throat, nose, or eyes. Donate Make a Donation Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. Bone marrow suppression can occur abruptly; factors likely to increase toxicity include advanced age, renal impairment, and concomitant use with another anti-folate drug e. Arthritis Network. Your doctor will tell you when to take folic acid. While on methotrexate you must limit yourself to 2 alcoholic beverages per week.
Common use

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.

Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.


Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.


This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.

Possible side effect

Methotrexate is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.

Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).

Missed dose

Consult your doctor if you miss a dose of this medicine.


Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.


Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.