NSAIDs nonsteroidal anti-inflammatory drugs - aspirin, ibuprofen Advil, Motrinnaproxen Alevecelecoxib, diclofenac, indomethacin, meloxicam, and others. All rights reserved. If taken as prescribed, these medications can work as quickly as 2 to 4 weeks. The most common adverse events are diarrhea, headache, nausea, abdominal pain, dyspepsia, vomiting, and rash. Drug: Pentasa Drug: Placebo. Actual Enrollment :. Pentasa Images. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. With oral use. Availability Prescription only. Modified-release tabletGastro-resistant tabletModified-release granulesFoamSuppositoryEnema.
||With oral use. Home Dosing. A plastic sleeve bearing administration instructions is provided for each Rectal Suspension bottle. Actual Primary Completion Date :. Overall, 45 Japanese ulcerative colitis UC patients receiving acute induction therapy with 4. FDA Resources. Patients with pulmonary disease, in particular asthma, should be very carefully monitored during a course of treatment. The Summary of Product Characteristics SPC or SmPC is a specific document, the wording of which has been agreed with the regulatory authority as part of the medicine approval process. If acute intolerance syndrome is suspected, prompt withdrawal is required. Contacts and Locations. Reasons for updating New SmPC for new product. Definitive nephrotoxicity and possible gastrointestinal toxicity is demonstrated in all species examined, and nephrotoxicity is evident with doses times those used in humans. Serum CRP is a laboratory measure of acute inflammation. FDA Resources. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Last Update Posted : March 16, As a guideline, follow-up tests are recommended 14 days after commencement of treatment, then a further two to three tests at intervals of 4 weeks.
Pentasa is a medication to treat ulcerative colitis. It belogs to the group of medications called aminosalicytates. It works by inhibiting the production of inflammatory chemicals in the lining of the colon. It descreases the production of prostaglandins and leukotrienes, chemicals that lead to the inflammation caused by ulcerative colitis.
Dosage and directions
Take is exactly as directed by your doctor. Follow all recommendations. Do not crush, break, or chew a mesalamine tablet or capsule. Swallow the pill whole.Call your doctor if you find undissolved tablets in your stool.
Discuss with your doctor if you have pyloric stenosis, allergy to sulfasalazine, congestive heart failure, liver or kidney disease.
Do not use the medicine if you have allergy to mesalamine or aspirin or other salicylates. Before using it discuss with you doctor if you have liver or kidney disease, pyloric stenosis, congestive heart failure, or a history of allergy to sulfasalazine.
Possible side effects
The severe side effects include: severe stomach pain, cramping, fever, headache, and bloody diarrhea. Less serious are mild nausea, vomiting, stomach cramps, diarrhea, gas; fever, sore throat, or other flu symptoms; constipation; headache or dizziness; tired feeling; or skin rash.
Tell your doctor about all other medications you may use, especially azathioprine (Imuran) or mercaptopurine (Purinethol); pentamidine (Nebupent, Pentam); tacrolimus (Prograf); amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet); antibiotics (capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled); antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid); or aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), diclofenac (Voltaren), etodolac (Lodine), indomethacin, nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek urgent medical help if you overdosed Pentasa. Overdose symptoms are ringing in your ears, dizziness, headache, confusion, drowsiness, sweating, shortness of breath, vomiting, and diarrhea.
Store at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Do not store in the bathroom. Keep it out of the reach of children and away from pets.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.