Rebetol
Generic Rebetol (Ribavirin)
Rebetol is used in combination with interferon drugs Intron A or PEG-Intron to treat chronic hepatitis C.
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Childhood Cancer Genomics. If a pregnancy occurs, your name may be listed on a pregnancy registry to Rebetol the effects of ribavirin on the baby. Rebetol Dosage Back to Top. Inosine monophosphate dehydrogenase IMDH is required for one of the metabolic pathways of azathioprine. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. In Study 3, there were 14 deaths, 2 of which were probable suicides and 1 was an unexplained death in a person with a relevant medical history of depression. Pregnant women or women who are trying to become pregnant cannot take ribavirin; women of childbearing age and their male sexual partners must use two forms of birth control throughout treatment and for six months post-treatment. If you have questions about what to do, call your healthcare provider. MavyretHarvoniEpclusaribavirinVoseviSovaldi. Ribavirin demonstrated increased incidences of mutation and cell transformation in multiple genotoxicity assays. Severe depression. Hepatitis C infection contributes to the deaths of an estimated 8, to 10, Americans each year and this toll is expected to triple by the yearaccording to the CDC. If vomiting occurs, advise patients to rinse out their mouth thoroughly afterwards. These are not all the possible side effects of Rebetol. Inform patients that in the event a dose is missed, the missed dose should be taken as soon as possible during the same day. Trademarks depicted herein are the property of their respective owners. Clinical Study 1 evaluated PegIntron monotherapy. A reference to a DNA virus is needed here. Rebetol in combination with Rebetll alfa 2b was also effective in Rebetpl with cirrhosis or HIV. Tell your healthcare provider if you have ever had any Rebetol problems. The dose your doctor recommends may be based on the following: the condition being treated other medical conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender Rebetol capsules and Rebegol are typically given as mg mg per day in two divided doses. Serious breathing problems. Rebetol has been approved in the United States since as part of a single-package combination therapy known as Rebetron that includes Rebetol capsules and Intron A injection. An increased risk when used in combination with pegylated alpha interferons and azathioprine Weight loss and slowed growth in children Tell your health care provider right away if you have any side effect that bothers you or that does not go away. Neither of these mechanisms explains ribavirin's effect on many DNA viruses, which is more of a mystery, especially given the complete inactivity of ribavirin's 2' deoxyribose analogue, which suggests that the drug functions only as an RNA nucleoside mimic, and never a DNA nucleoside mimic. The Journal of Antimicrobial Chemotherapy. This drug shows a similar spectrum of antiviral activity to ribavirin, which is not surprising as it is now known to be a pro-drug for ribavirin. However, a key difference between the structure of Ribavirin and the purine nucleosides is that the cyclic attachment to the ribose in Ribavirin contains only one ring, as opposed to purines which are heterocyclic. August 31, Grants Policies and Process. Priority review status is granted to drugs that, if approved, would address unmet medical needs and represent significant advances over existing treatments. Intramural Research. Metastatic Cancer Research. Stories of Discovery. Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Rebetol. Ribavirin can cause dry mouth, which could lead to tooth decay or gum disease. Questions to Ask about Your Treatment. Rebetol and Lactation Back to Top. Step 3: Peer Review and Funding Outcomes. Milestones in Cancer Research and Discovery. Spotlight on Scientists. Do not allow it to freeze. Popular Emailed Recent Loading Cancer Treatment Research. Not all possible drug interactions are listed here. In this viewpoint, Kavanagh, et al. Nursing mothers: not recommended.

Rebetol - you

Before you take Rebetol, tell your healthcare provider if you have Rdbetol ever had: treatment for Rebstol C that did not work for you. Advise patients that laboratory evaluations are required prior to starting therapy and periodically thereafter [see Dosage and Administration 2. Gastrointestinal Disorders. Feelings and Cancer. Advise patients to notify the physician immediately in the event of a pregnancy [see Contraindications 4Warnings and Precautions 5. Rebetol is thought to interfere with the production or action of viral DNA and RNA, which are needed for viruses to survive and multiply.

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Advise patients to be well hydrated, especially during the initial Rebettol of treatment. In general, REBETOL capsules should be administered to elderly patients cautiously, starting at Reetol lower end of the dosing range, reflecting the greater frequency of decreased Rebettol and cardiac function, and of concomitant disease or other drug therapy. Risk Factors. Ninety-four of Reberol enrolled in a 5-year follow-up trial. Trial results are summarized in Table Inform patients that in the event a dose is Rebetol, the Rebrtol dose should be taken as soon as possible during the same Rebeto. Funding Strategy. Decreases in hemoglobin, leukocytes, neutrophils, and platelets Rebetoo require dose reduction or permanent discontinuation from therapy [see Dosage and Administration 2. Ribavirin demonstrated increased incidences of mutation and cell transformation in multiple genotoxicity assays. Based on results of clinical trials, ribavirin monotherapy is not effective for the treatment of chronic hepatitis C virus infection; therefore, REBETOL capsules or oral solution must not be used alone. Chronic hepatitis C infection can cause serious liver problems such as scarring cirrhosisor liver cancer. The typical pattern observed was a decrease in hemoglobin levels by treatment Week 4 followed by stabilization and a plateau, which was maintained to the end of treatment [see Dosage and Administration 2. Clicking on any of the links below will take you to a website intended for those living outside the United States and Canada. A total of 1, subjects weighing greater than 65 kg in Study 3 had genotype 2 or 3 and were randomized to 24 or 48 weeks of therapy. Transfer of a Grant. Weight and height gain of pediatric subjects treated with PegIntron plus REBETOL lagged behind that predicted by normative population data for the entire length of treatment. Blood chemistries - liver function tests and TSH. Strategic Planning. Long-term follow-up data in pediatric subjects, however, indicates that PegIntron in combination therapy with REBETOL may induce a growth inhibition that results in reduced adult height in some patients [see Adverse Reactions 6. Funding Strategy. Other drugs may interact with ribavirin, including prescription and over-the-counter medicines, vitaminsand herbal products. Such hypermutation can be lethal to RNA viruses. When you enter three or more characters, Rebetol list of up to 10 suggestions will popup under the textbox. It is not to be confused with taribavirin. Availability Prescription only. Side Effects of Rebetol Back to Top. The medication has two FDA "black box" warnings: One raises concerns that use before or during pregnancy by either sex may result in birth defects in the baby, and the other is regarding the risk of red blood cell breakdown. Severe blood disorders. Figure 3. Get Best Price. This type of transporter is present on virtually all cell types and may account for the extensive volume of distribution. As in adult patients, pediatric patients experienced other psychiatric adverse reactions e. Side Effects of Rebetol Back to Top. Before you take Rebetol, tell your healthcare provider if you have or ever had: treatment for hepatitis C that did not work for you. NDC National Drug Code - Each drug product is assigned this unique number which can be found on the drug's outer packaging. Use this Search to quickly find items or navigate the site. Autoimmune disorders. Jump to navigation. Severe depression. Patients should be assessed for underlying cardiac disease before initiation of ribavirin therapy. Concomitant didanosine. Refer to labeling for PegIntron for additional information. It is predicted that direct U. What measures are being taken to ensure the safe and effective use of Rebetol? Only subjects with at least one treatment value for a given laboratory test are included. Other drugs may interact with ribavirin, including prescription and over-the-counter medicines, vitaminsand herbal products. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Why has Rebetol been approved? Serious breathing problems. You should not use Rebetol if you have autoimmune hepatitis, severe kidney disease, or a hemoglobin blood cell disorder. Rebetol for ribavirin resistance is not commercially available. Another possible mechanism involves the enhancement of interferon-stimulated gene ISG expression by Ribavirin. Verified Supplier. Cancer Causes and Prevention. Grant Closeout. Rebetol Ask Price. Hepatitis C Online. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Consequently, the company will not update the information contained in the website and investors should not rely upon the information as current or accurate after the presentation date. Views Article Discussion Edit this page History. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rebetol only for the indication prescribed. Mumbai Shop No. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If you have questions about what to do, call your healthcare provider. Pregnant women or women who are trying to become pregnant cannot take ribavirin; women of childbearing age and their male sexual partners must use two forms of birth control throughout treatment and for six months post-treatment. Ribavirin has direct antiviral activity in cell culture against many RNA viruses. Always consult your healthcare provider to ensure Rebetol Rebeto, displayed on this page applies to your personal circumstances. If you become anemic while on ribavirin, your medical provider may need to adjust the dose accordingly. Subjects with the following characteristics were less likely to benefit from re-treatment: previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and genotype 1 infection. Malformations of the skull, palate, eye, jaw, limbs, skeleton, and gastrointestinal tract were noted. Patients should be assessed for underlying cardiac disease before initiation of ribavirin therapy. Subjects developed new onset TSH abnormalities while on treatment and during the follow-up period. As in adult patients, pediatric patients experienced other psychiatric adverse reactions e.
Common use

Main component of antiviral drug Rebetol is Ribavirin. It is used in combination with interferon drugs Intron A or PEG-Intron to treat chronic hepatitis C. Rebetol inhibits the replication of new virions, selectively inhibits synthesis of viral RNA, it does not suppress synthesis of RNA in a normal cells. Rebetol is the most effective against: herpes simplex virus, virus of smallpox, influenza viruses A and B, paramyxovirus (parainfluenza, mumps, Newcastle disease), reovirus, oncogenic RNA viruses.



Dosage and direction

Make sure you drink plenty of water while taking Rebetol, especially with your first intakes of the medication. Treatment continues for 24-48 weeks. To treat hepatitis C take Rebetol orally with food and full glass of water. Do not chew the tablet, swallow it whole. Recommended dose of Rebetol is 1-1.2 g a day divided in two for morning and evening intakes.



Precautions

Rebetol is may cause a significant risk of serious harm to developing infants and abnormalities in a man's sperm, be very attentive using contraception medications. At least two forms of birth control during treatment and for six months afterwards are required.



Contraindications

Rebetol is contraindicated in patients hypersensitive to the components of Rebetol, in pregnant and breastfeedign women, in patients with chronic heart failure, myocardial infarction, kidney or liver failure, severe anemia, decompensated cirrhosis, autoimmune diseases, incurable thyroid disease, severe depression with suicidal intentions, children and adolescents under 18. Cautiousness should be exercised in patients with decompensated diabetes mellitus, pulmonary embolism, heart failure, thyroid disease (including hyperthyroidism), impaired clotting, thrombophlebitis, myelosuppression, haemoglobinopathy (thalassemia, sickle cell anemia), depression, suicidality (also in history).



Possible side effect

The most serious adverse reaction to Rebetol is anemia. Other side effects include: blood disorders, fever, hair loss, depression, fatigue, headache, insomnia, irritability, nausea, shortness of breath, joint or muscle pain, weight loss. Notify your doctor immediately if you experience any serious manifestation of the side effects listed above.



Drug interaction

Concomitant use with other antiviral drugs such as zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit), may cause lactic acidosis. Medications which contain Mg2+ Г‰ Al3+, and also simethicone decrease absorption of Retrovir. Retrovir suppresses effects of zidovudine. In the patients with HIV infection concomitant treatment with Retrovir, zidovudine and stavudine leads to HIV viremia (a condition where viruses get into the bloodstream and can affect the rest of the body) and requires change of treatment.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

If you suppose that took too much of this medication seek immediate medical attention. There is no information about adverse effects of Rebetol overdose.



Storage

Rebetol should be stored at room temperature between 2-8 C (36-46 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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